diabetes therapy journal

Youm, Y.-H.; Nguyen, K.Y. image, https://www.sst.dk/-/media/Udgivelser/2017/Det-danske-sundhedsv%C3%A6sen/Det-Danske-Sundhedsv%C3%A6sen,-d-,-Engelsk.ashx, https://laegemiddelstyrelsen.dk/en/reimbursement/calculate-reimbursement/reimbursement-thresholds/, https://www.ema.europa.eu/en/news/ema-confirms-recommendations-minimise-ketoacidosis-risk-sglt2-inhibitors-diabetes, Download .docx (4.44 Participation on advisory board for Astra Zeneca and Boehringer Ingelheim. In addition, dapagliflozin, empagliflozin, and sotagliflozin are also recommended (IA) for patients with type 2 diabetes and HfrEF to reduce HF-related hospitalizations and cardiovascular death [, Due to the effectiveness of SGLT2 inhibitors in the treatment of heart failure and their pleiotropic mechanism of action, there are increasing attempts to use this group of drugs in other cardiovascular diseases. https://www.mdpi.com/openaccess. Since the introduction of sodium-glucose cotransporter-2 inhibitors (SGLT2-i) in 2013 and glucagon-like peptide-1 receptor agonists (GLP-1RA) in 2006 for the treatment of type 2 diabetes (T2D), both agents have come a long way proving to have beneficial effects in a broad spectrum of diseases. Estimating proportion of days covered (PDC) using real-world online medicine suppliers' datasets. S1S16. ; Antonio, E.L.; Pacheco, B.P.M. Preclinical studies on animal models of myocardial ischemia-reperfusion injury showed that the use of gliflozins could be associated with a reduced infarct size [, Another area of interest is related to the use of SGLT2 inhibitors to prevent arrhythmias and sudden cardiac death. Please note that many of the page functionalities won't work as expected without javascript enabled. Also, the risk of discontinuation followed the risk of discontinuing other of cardioprotective drugs (metformin, statins, and RAS-inhibitors). Resources Find an Endocrinologist (referral): www.hormone.org or call 1-800-HORMONE (1-800-467-6663) American Diabetes Association: www.diabetes.org or call 1-800-342-2383 Jesper Jensen: reports grants from The Danish Heart Foundation, CARDIO-HGH Foundation. ; Broedl, U.C. Compared with the DAPA-HF trial, the participants of the EMPEROR-Reduced trial had lower baseline LVEF, were more often treated with ARNIs, and had higher NT-proBNP levels (. ; Butler, J.; Filippatos, G.; Pocock, S.J. ; Voors, A.A.; Metra, M.; et al. The effect of dapagliflozin treatment on epicardial adipose tissue volume. ; Li, Q.; Perkovic, V.; Mahaffey, K.W. The STEPS approach can help choose subsequent medications if metformin does not provide adequate glycemic control. EMA confirms recommendations to minimise ketoacidosis risk with SGLT2 inhibitors for diabetes. Canagliflozin reduces epicardial fat in patients with type 2 diabetes mellitus. ; Mosenzon, O.; Kato, E.T. The alpha-glucosidase inhibitor acarbose (Precose) has evidence to support improved patient-oriented outcomes,18 and as with metformin, its price is quite low. Kramer, C.K. methods, instructions or products referred to in the content. Verma, S.; Mazer, C.D. Effect of Empagliflozin on Left Ventricular Mass and Diastolic Function in Individuals with Diabetes: An Important Clue to the EMPA-REG OUTCOME Trial? This hybrid open-access journal is an official title of Diabetes UK, which over that the last decade has invested 67+ million in diabetes research. ; McMurray, J.J.V. 2023 Springer Nature Switzerland AG. However, under hyperglycemic conditions, the reabsorption of glucose and sodium is increased. 10. ; Bengtsson, O.; et al. Improving compliance with SGLT2 inhibitors by reducing the risk of genital mycotic infections: The outcomes of personal hygiene advice. Now, family physicians have approximately 40 medications in 10 categories to manage hyperglycemia in patients with type 2 diabetes. As HF progresses, the activity of enzymes involved in mitochondrial fatty acid oxidation decreases. ; Ponikowski, P.; DeMets, D.L. 25 Issue 3 CURRENT ISSUE pp.157-216 February 2023 Vol. The first group was given dapagliflozin (10 mg), while the other group received placebo. Approximately half of the users of SGLT2-is and GLP1-RAs discontinued therapy within five years, respectively. This study showed that despite a recent decline, a high incidence of CKD in the United States persists. Only a few years ago, lifestyle modification, sulfonylureas, metformin, and insulin were the only treatment options for type 2 diabetes mellitus. A person viewing it online may make one printout of the material and may use that printout only for his or her personal, non-commercial reference. and A.T.; validation, D.K., B.H. Due to the different mechanisms of action of these drugs, their combined effect can change the natural course of HF by reducing the risk of hospitalization and death from HF. Copyright 2023 Elsevier Inc. except certain content provided by third parties. Katherine R. Tuttle, M.D. The aim is to provide a snapshot of some of the The absolute five-year risk of discontinuing therapy was 56% (95% CI: 5557) and 45% (4546) for SGLT2-i- and GLP1-RA users, respectively, with a significantly decreased risk over the period studied. Drug Targets Cardiovasc. The number of persons with diabetes is projected to grow from 463 million to 700 million worldwide between 2019 and . ; Horton, J.L. ; Kber, L.; Kosiborod, M.N. Bailey, C.J. ; Mahaffey, K.W. ; de Zeeuw, D.; Vercruysse, F.; Shaw, W.; Matthews, D.R. This phenomenon may help control peripheral edema without adverse effects on arterial perfusion in patients with HF [, The reduction in systolic blood pressure during treatment with gliflozins is due to a diuretic effect and a decrease in afterload due to reduced arterial stiffness [, A series of studies on animal models showed beneficial effects of SGLT2 inhibitors on the myocardium. The Standard of Care in Type 2 Diabetes: Re-evaluating the Treatment Paradigm. Poor memory, eyesight, or health literacy may make such a challenging regimen a poor option for some patients. https://doi.org/10.3390/jcdd9070225, Kurczyski D, Hudzik B, Jagosz M, Zabierowski J, Nowak J, Tomasik A, Badziski A, Rozentryt P, Gsior M. Sodium-Glucose Cotransporter-2 Inhibitors-from the Treatment of Diabetes to Therapy of Chronic Heart Failure. Patients who discontinued SGLT2-i or GLP1-RA therapy during the five-year follow-up period, were included in additional analyses where the probability of reinitiating therapy over the subsequent year was assessed. Mediators of the Effects of Canagliflozin on Heart Failure in Patients with Type 2 Diabetes. Yasui, A.; Lee, G.; Hirase, T.; Kaneko, T.; Kaspers, S.; von Eynatten, M.; Okamura, T. Empagliflozin Induces Transient Diuresis without Changing Long-Term Overall Fluid Balance in Japanese Patients with Type 2 Diabetes. Albiglutide and cardiovascular outcomes in patients with type 2 diabetes and cardiovascular disease (Harmony Outcomes): a double-blind, randomised placebo-controlled trial. In addition, hypertension was also defined from concurrent use of at least two antihypertensive therapies. Additional subgroup analyses of the outcomes mentioned above, were performed in patients with and without cardiovascular disease (defined as heart failure, ischemic heart disease, acute myocardial infarction, peripheral artery disease, atrial fibrillation/flutter and stroke), in different calendar periods, in age groups and by sex. 25 Issue S2 pp.A-1-A-284 Visit our dedicated information section to learn more about MDPI. Further insight into the reasons for discontinuation and initiatives to reduce the time to reinitiation in eligible patients are warranted. ; Solomon, S.D. a and b) and one-year cumulative incidence of reinitiation of therapy (Fig. ; Lindberg, M.; Rossing, P.; et al. ; Zelniker, T.A. No special Charlotte Andersson: data interpretation, writing - review and editing. If you would like to request a discount or waiver please do so either ahead of submission or at the very start of the submission process. List, J.F. ; Anker, S.D. ; methodology, D.K., J.N. Effects of canagliflozin on amputation risk in type 2 diabetes: The CANVAS Program. ; Badimon, J.J. Metabolism of the failing heart and the impact of SGLT2 inhibitors. Dev. c and d) with 95% confidence intervals. official website and that any information you provide is encrypted Zelniker, T.A. Having diabetes requires that you take care of yourself every day. Strojek, K.; Yoon, K.H. Renoprotective effect of the angiotensin-receptor antagonist irbesartan in patients with nephropathy due to type 2 diabetes. ; Garro, M.; Barron, B.; Mayoux, E.; Rector, R.S. Dapagliflozin versus glipizide as add-on therapy in patients with type 2 diabetes who have inadequate glycemic control with metformin: A randomized, 52-week, double-blind, active-controlled noninferiority trial. ; Al-Omran, M.; Sabongui, A.; Teoh, H.; Mazer, C.D. ; Rizkala, A.R. 11 2020 Vol. Our patients with diabetes depend on us to help reduce their long-term risk of myocardial infarction, stroke, amputation, dialysis, and premature mortality. Dapagliflozin, a selective SGLT2 Inhibitor, attenuated cardiac fibrosis by regulating the macrophage polarization via STAT3 signaling in infarcted rat hearts. Transitions of care for people with type 2 diabetes: utilization of antihyperglycemic agents pre- and post-hospitalization. 2019 ESC guidelines on diabetes, pre-diabetes, and cardiovascular diseases developed in collaboration with the EASD. This leading international journal delivers practical information and comprehensive coverage of cutting-edge technologies and therapeutics in the field, and each issue highlights new pharmacological and device developments to optimize patient care. The Danish Civil Registration System as a tool in epidemiology. Crown Copyright 2023 Published by Elsevier Ltd. In two cohorts, we identified and included all T2D patients redeeming the first prescription of a SGLT2-i between January 1, 2013, and December 31, 2021. Mcmurray: reports payment or honoraria for lectures/presentations/speaker bureaus/manuscript writing for Abott, Alkem Metabolics, Eris Lifesciences, Hikma, Lupin, Sun Pharmaceuticals, Supplemental_clean-LancetEU. ; Johansen, O.E. ; Correa-Rotter, R.; Greene, T.; Hou, F.-F.; Lindberg, M.; McMurray, J.; Rossing, P.; Toto, R.; et al. Department of Cardiology, Copenhagen University Hospital Herlev and Gentofte, Denmark, Department of Cardiology, Zealand University Hospital, University of Copenhagen, Roskilde, Denmark, Department of Cardiology, Rigshospitalet, Copenhagen University Hospital, Copenhagen, Denmark, Division of Cardiovascular Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA, BHF Cardiovascular Research Centre, University of Glasgow, Glasgow, UK. ; Jhund, P.S. For more information, please refer to ; Hansen, T.B. Avoid the most common mistakes and prepare your manuscript for journal editors. ; Kber, L.; Kosiborod, M.N. ; Lewis, J.B.; Ritz, E.; Atkins, R.C. Docherty, K.F. Voros, G.; Ector, J.; Garweg, C.; Droogne, W.; Van Cleemput, J.; Peersman, N.; Vermeersch, P.; Janssens, S. Increased Cardiac Uptake of Ketone Bodies and Free Fatty Acids in Human Heart Failure and Hypertrophic Left Ventricular Remodeling. Later, sodium-glucose transporters were discovered. In the most recent ESC HF guidelines, there is the concept of patient phenotyping, particularly in comorbidities. Of the patients who discontinued therapy, around one-quarter reinitiated therapy shortly after. Conceptualization, D.K., J.N. Department of Cardiology, Copenhagen University Hospital Herlev and Gentofte, Cardiovascular Research Unit 1, Postbox 635 Gentofte Hospitalsvej 6, DK-2900, Hellerup, Denmark. December 15, Most of them were given diuretics. Present diabetes guidelines are based on a shared decision-making approach with consideration of patient preferences when choosing antihyperglycemic therapy. Herat, L.; Magno, A.; Rudnicka, C.; Hricova, J.; Carnagarin, R.; Ward, N.; Arcambal, A.; Kiuchi, M.G. and J.N. Trials and systematic reviews referenced in the 2017 American Diabetes Association guideline and package inserts of newer medications, and selected relevant references were used. Factors associated with discontinuation of SGLT2-i. Tanaka, H.; Takano, K.; Iijima, H.; Kubo, H.; Maruyama, N.; Hashimoto, T.; Arakawa, K.; Togo, M.; Inagaki, N.; Kaku, K. Factors Affecting Canagliflozin-Induced Transient Urine Volume Increase in Patients with Type 2 Diabetes Mellitus. You will then receive an email that contains a secure link for resetting your password, If the address matches a valid account an email will be sent to __email__ with instructions for resetting your password. Lars Kber: methodology, supervision, data interpretation, writing - review and editing. impact of dapagliflozin on left ventricular diastolic function of patients with type 2 diabetic mellitus with chronic heart failure. a) and GLP1-1 users (Fig. The Effects of Sodium-Glucose Cotransporter 2 Inhibitors on Sympathetic Nervous Activity. This process may lead to a decrease in adenosine triphosphate (ATP) production and progression of HF [, Increased expression of enzymes involved in the metabolism of ketone bodies is reported in cardiomyocytes of the failing heart. Patients who redeemed prescriptions of Saxenda (liraglutide), were not considered as Saxenda is indicated primarily for chronic weight management in obese adults and not for the treatment of T2D. Sub analysis of a clinical trial. 2021 ESC Guidelines for the diagnosis and treatment of acute and chronic heart failure: Developed by the Task Force for the diagnosis and treatment of acute and chronic heart failure of the European Society of Cardiology (ESC) with the special contribution of the Heart Failure Association (HFA) of the ESC. (2) Methods: This study was designed as an open-labelled randomized trial. Personal service: The journals team will re-format articles and upload submissions on behalf of authors, if necessary. John J.V. H index. ; Alam, U.; Cuthbertson, D.J. Baseline characteristics of SGLT2-i- and GLP1-i users. March 6, Of the SGLT2-i users, 58% (24,660) were adherent to therapy over the first year with a mean PDC of 70% (SD 30) and 60% (15,799) of the GLP1-RA users were adherent to therapy with a mean PDC of 73% (SD 27) (, All patients, regardless of follow-up time, were considered in this analysis, which comprised 75,745 users of SGLT2-i and 56,037 users of GLP1-RA, respectively. Note that from the first issue of 2016, this journal uses article numbers instead of page numbers. Empagliflozin, cardiovascular outcomes, and mortality in type 2 diabetes. Oral semaglutide (Rybelsus) was not included in this analysis due to the limited follow-up as they were introduced in Denmark in 2021. Several recent large randomized controlled trials have significantly improved physicians' knowledge about the impact of medications for type 2 diabetes mellitus on patient-oriented outcomes. 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