dendrimer nanoparticles

Initially, the cTnI biomolecules were immobilized on the surface of a gold nanoparticle-functionalized screen-printed graphite electrode (SPGE). Systemic delivery of dual-modal nanoparticles led to accumulation of the agents in a flank mouse . J Pharmaceut Biomed. We also designed a DH formulation to deliver the anticancer drug CPT via conjugation [47]. 2a) [28, 29]. We modified parameters to make dendrimer nanogels and tested them for topical delivery of antiglaucoma drugs [111]. Structure diversity, adaptability and flexible cargo loading capacity of dendrimers. J Biol Eng 16, 18 (2022). Biomaterials. These complexes are particularly useful for their adjustable size, biocompatibility and low toxicity [27, 28]. ACS Nano. The dendrimer is used as a versatile drug delivery nanovehicle in nanomedicine. Multifunctional dendrimers carry antitumor drugs on their surfaces and can also be modified by solubilizing functions and tumor-targeting ligands. Yang H, Morris JJ, Lopina ST. Polyethylene glycolpolyamidoamine dendritic micelle as solubility enhancer and the effect of the length of polyethylene glycol arms on the solubility of pyrene in water. For instance, dendrimers with a hydrophobic core and a hydrophilic periphery may behave like unimolecular micelles, and they have been utilized to solubilize hydrophobic drugs by entrapping them in the intramolecular cavity [25, 26]. 2b) [25]. Eur J Pharm Sci. Launay N, Caminade A-M, Lahana R, Majoral J-P. A general synthetic strategy for neutral phosphorus-containing dendrimers. Academic Press; 2019. p. 20531. 2018;15:28839. Wang J, Li B, Huang D, Norat P, Grannonico M, Cooper RC, et al. 20822041D4094, 1082204112665) and the National Natural Science Foundation of China (52103177). Pryor JB, Harper BJ, Harper SL. Amine-terminated PAMAM dendrimers have been broadly used as gene transfection vectors (Fig. 1 , 2 In this review, we will discuss these . 2a) [28]. Journal of Polymer Research 2022 TLDR The developed nano-carrier based on the third generation of polyamidoamine dendrimer, grafted with polyethylene glycol and folic acid for oral delivery of Imatinib with sustained release showed efficient entrapment of IM drug, and a sustained release was observed for nano-complexes in physiological conditions. marcondes, pollyana; rosas, gisela h.; gonzalez, maria e.l.; queiroz, alvaro a.a. de; marques, paulo s. Deoxyribonucleic acid (DNA) was electrostatically condensed by a positively charged poly{N-[2-(acryloyloxy)ethyl]-N-[p-(2,4-dinitrophenoxy)benzyl]-N,N-diethyl ammonium chloride} (PADDAC) polymer and coated with a liposome layer to maintain the stability in blood circulation. J Control Release. But it is of paramount importance to retain the formulation locally. Kurtoglu YE, Mishra MK, Kannan S, Kannan RM. Recent developments that have been made to address the challenges mentioned above are summarized below. Linear polyethyleneimine-based charge-reversal nanoparticles for nuclear-targeted drug delivery. Since the synthesis of PAMAM dendrimer is also based on the aza-Michael addition between amine and acrylate groups, the formed gel has similar chemical linkages to the original dendrimers. Hit : 2; Download : 0; Export. The maltodextrin-derived dendritic nanoparticle was fabricated using microbial branching enzyme and its structural characterizations were investigated Lancina MG, Wang J, Williamson GS, Yang H. DenTimol as a dendrimeric timolol analogue for glaucoma therapy: synthesis and preliminary efficacy and safety assessment. Int J Nanomed. 2005;2:27894. 2018;13:168891. Small. constructed size- and charge-adaptive clustered nanoparticles based on the electrostatic interaction between PAMAM and 2,3-dimethyl maleic anhydride modified poly(ethylene glycol)-block-polylysine (PEG-b-PLys) [69]. 2017;9:4245970. 2021;17:2102695. 2011;21:1911423. Tomalia DA, Hedstrand DM, Ferritto MS. Comb-burst dendrimer topology: new macromolecular architecture derived from dendritic grafting. Furthermore, thanks to the development of various synthetic strategies, including efficient orthogonal click chemistry and multicomponent reaction (MCR), many new dendrimers with the efficient synthetic process and structure diversity have emerged [16,17,18,19]. 2020;2:1507. Figure 2 In addition, we offer dendrimer polymers modified with acetylene, ammonium, azide, carboxyl . Al-Jamal KT, Al-Jamal WT, Kostarelos K, Turton JA, Florence AT. 2018;23:2849. Hua Y, Chen L, Hou C, Liu S, Pei Z, Lu Y. Supramolecular vesicles based on amphiphilic pillar[n]arenes for smart nano-drug delivery. Liu X, Xiang J, Zhu D, Jiang L, Zhou Z, Tang J, et al. Nevertheless, such a strategy impedes dendrimer tissue penetration and subsequent cell internalization. ACS Nano. 2015;18:56572. studied the toxicity of PAMAM on embryonic zebrafish models and found that cationic PAMAM generation 6 was statistically more toxic than both neutral PAMAM generation 6 and anionic PAMAM generation 6 at the same concentration [68]. Wang G, Wu B, Li Q, Chen S, Jin X, Liu Y, et al. In this study, we designed a manganese-based and hypericin-loaded polyester dendrimer nanoparticle (MHD) for magnetic resonance imaging (MRI) and hypericin-based photodynamic therapy (PDT) enhancement. PEGylation of dendrimers is commonly used to shield the cationic surface of dendrimers, reduce their toxicity, and prolong their circulation time [72, 73]. Dendrimer-RNA nanoparticles generate protective immunity against lethal Ebola, H1N1 influenza, and Toxoplasma gondii challenges with a single dose Vaccines have had broad medical impact, but existing vaccine technologies and production methods are limited in their ability to respond rapidly to evolving and emerging pathogens, or sudden outbreaks. Gokay SS, Celik T, Sari YM, Ekinci F, Yildizdas RD, Yilmaz HL. Therefore, it is important to examine the release of drugs from dendrimer-drug conjugates (Fig. The controlled self-cleaving release mechanism significantly prolonged CPT release and thus enhanced tumor inhibition. Zhou L, Gan L, Li H, Yang X. New core-shell architectures address the drawbacks of initial approaches . Gao et al. Preparation and Characterization of 12 nm Dendrimer-Encapsulated Gold Nanoparticles Having Very Narrow Size Distributions. Its highly branched molecular structure, surface multifunctional functional groups and spherical structure show unique application performance as adhesion promoter, which can not only participate in curing, improve cross-linked structure and effectively improve the toughness of the coating, it can also improve the adhesion and shear . Chem Rev. Jackson CL, Chanzy HD, Booy FP, Drake BJ, Tomalia DA, Bauer BJ, Amis EJ. Here, we develop a rapid-response, fully synthetic, single-dose, adjuvant-free dendrimer nanoparticle vaccine platform wherein antigens are encoded by encapsulated mRNA replicons. Preparation and evaluation of PAMAM dendrimer-based polymer gels physically cross-linked by hydrogen bonding. The distinct synthetic process makes dendrimer possess a well-defined coreshell architecture and narrow polydispersity [1, 9]. They produced polymers with a central, hollow core and tendrils that branched outward, one from another, in a precise, predictable manner, which Tomalia called dendrimers [4]. Acetylation of amine groups can decrease the positive surface charges of PAMAM dendrimer and thus reduce its toxicity. These catalysts are air stable, very active, robust, and recyclable during the process. 2007;43:3304. 2021;204: 111837. 2001;6:42736. 2014;26:41637. Hsieh-Chih Tsai, Toyoko Imae, in Progress in Molecular Biology and Translational Science, 2011. . This mini review article provides a brief overview of dendrimers history and properties and the latest developments of dendrimers as drug delivery systems. J Intern Med. 2016;17:123552. Then, PAMAM was anchored on the surface of CNPs. Monometallic, bimetallic (alloy and core@shell), and semiconductor nanoparticles have been prepared by this route. Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. 2021;148: 110356. A new class of polymers: starburst-dendritic macromolecules. In addition to the delivery methods discussed above, drugs and/or genes can be in-situ embedded in the hydrogel network. The repeated growth reactions during dendrimer synthesis lead to higher generation and degree of branching, eventually forming a three-dimensional spherical structure [20]. Dendrimer-polysaccharide conjugates are usually adopted to endow the nanomaterials with attractive binding properties and improved compatibility [30, 32, 33]. 2020;244: 122641. Juan Wang was supported by the Fundamental Research Funds for the Central Universities of China (Grant No. 2016;222:11629. The positive surface charged G3-acetal-NH2 has a similar pMAXGFP plasmid condensing capacity to that of native PAMAM G4. Many chemical and physical ways were developed to cross-link dendrimers to form hydrogels [97,98,99,100,101,102,103]. Subconjunctival injectable dendrimer-dexamethasone gel for the treatment of corneal inflammation. Up to now, more than 100 dendritic structures have been reported, in which polyamidoamine (PAMAM) dendrimers, polypropyleneimine (PPI) dendrimers, as well as polyamide-, polyether-, polyester-, and phosphorus-based dendrimers are some of the most commonly recognized dendritic families [2, 3, 5,6,7,8,9,10,11,12,13,14,15] (Table 1). Compared with branched polyethylenimine (PEI), PAMAM dendrimers show higher biocompatibility and larger nucleic acid loading capacity [52]. Encapsulation of doxorubicin within multifunctional gadolinium-loaded . J Pharm Bioall Sci. It is thus vital to develop multifunctional theranostic nanoparticles for the visualization and dynamic monitoring of tumor therapy. Int J Pharm. The Janus dendrimer comprises two distinct dendrons: one is hydrophilic and zwitterionic end-group functionalized, the other is modified with positively charged arginine groups and hydrophobic moieties. Although there are many types of dendrimers, the most common is the poly(amidoamine) (PAMAM) dendrimer. This loosely three-dimensional network of the DH formulation enables a two-phase drug release kinetics: a burst release within the first 6h allows the drug to rapidly reach an effective concentration, and a subsequent sustained release continuously supplies the drug to maintain the therapeutic drug level for 48h. The corneal permeability of brimonidine by using this mildly cross-linked DH increased by two-fold. What is more interesting is that the ammonolysis process is pH-dependent: a more acidic environment tends to slow down the ammonolysis and extend gel degradation [104]. Agrawal P, Gupta U, Jain NK. Eur Polym J. Desai PN, Yuan Q, Yang H. Synthesis and characterization of photocurable polyamidoamine dendrimer hydrogels as a versatile platform for tissue engineering and drug delivery. 2015;6:28606. 1999;99:166588. 3) [97]. Pharm Res. The first component in DEN synthesis is the dendrimer itself. Dendrimer-based Nanoparticles for Cancer Treatment Two technical advances underlie our research. Accelerated blood clearance phenomenon reduces the passive targeting of PEGylated nanoparticles in peripheral arterial disease. Keywords: dendrimers dendrons gold nanoparticles MRI optical imaging quantum dots superparamagnetic iron oxide tumor targeting Finally, the dendrimer encapsulated nanoparticles (DENs) were applied as catalysts in the oxidation of n-octane. 2005;57:2177202. The reduction in the dendrimer surface charge resulted in the release of the genetic payload and enhanced GFP protein expression. Wang J, Cooper RC, He H, Li B, Yang H. Polyamidoamine dendrimer microgels: hierarchical arrangement of dendrimers into micrometer domains with expanded structural features for programmable drug delivery and release. Despite the benefits of dendrimers as drug delivery carriers, some challenges remain to be solved. A widely studied use of PAMAM dendrimers is with the incorporation . They are mostly hundreds of nanometers in size and remain stable during blood circulation. Thiagarajan G, Greish K, Ghandehari H. Charge affects the oral toxicity of poly(amidoamine) dendrimers. Wang D, Astruc D. Dendritic catalysisbasic concepts and recent trends. For instance, the half-life of methotrexate is increased to 24h from 24min when conjugated with PAMAM dendrimer [29]. HR-TEM results indicate relatively uniform particles with an average particle size falling in the range of 4-6 nm. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data. It is desirable to design a spatiotemporally controllable gene delivery vehicle to release nucleic acids intracellularly. Dendrimer-drug conjugates could reduce systemic effects and increase efficacy at the targeted site compared with free drugs [25, 39]. However, they have a very different structure from classical polymers, which makes them unique. As the incidence of diabetes steadily increases, so does the number of chronic wounds ( 34 ), which supports the need for novel treatment. 2010;384:18994. 2013;65:120414. Dendrimer chemistry: concepts, syntheses, properties, applications. 2005;10:3464. Importantly, cross-linking dendrimer with PEG makes the cross-linked structure more biocompatible compared to free dendrimers in equivalent molar qualities [97, 105]. Macromolecules. dendrimeric nanoparticles are created, which can be used in conjunction with a variety of in vitro and in vivo diagnostic systems. Arima H, Motoyama K, Higashi T. Sugar-appended polyamidoamine dendrimer conjugates with cyclodextrins as cell-specific non-viral vectors. 2019;215: 119233. DOI: 10.1007/s10904-020-01705-4 Corpus ID: 221364754; Application of Dendrimer/Gold Nanoparticles in Cancer Therapy: A Review @article{Nabavifard2020ApplicationOD, title={Application of Dendrimer/Gold Nanoparticles in Cancer Therapy: A Review}, author={Samaneh Nabavifard and Shirin Jalili and Fereshteh Rahmati and Yasser Vasseghian and Gomaa A. M. Ali and Shilpi Agarwal and Vinod K. Gupta . Dendrimers have been widely adopted as drug/gene delivery vehicles in various forms, including dendrimer-drug conjugates, drug/dendrimer encapsulation, dendrimer/gene complexation, and so on. ACS Appl Mater Interfaces. However, long-term administration of PEGylated formulations leads to the accumulation of PEGs within tissues, leading to potential tissue toxicity and adverse effects [76,77,78]. Dendrimer-Based Lipid Nanoparticles Deliver Therapeutic FAH mRNA to Normalize Liver Function and Extend Survival in a Mouse Model of Hepatorenal Tyrosinemia Type I Dendrimer-Based Lipid Nanoparticles Deliver Therapeutic FAH mRNA to Normalize Liver Function and Extend Survival in a Mouse Model of Hepatorenal Tyrosinemia Type I 2013;102:236270. Macromolecules. Chem Mater. 2018;51:61118. If drugs can be cleaved from dendrimer-drug conjugates and maintain their initial structure, this bureaucratic regulation issue could be avoided. For instance, microfluidic technology or flow chemistry may help produce dendrimer microgels with uniform size as well as increase production efficiency. Comparative studies on the genotoxicity and cytotoxicity of polymeric gene carriers polyethylenimine (PEI) and polyamidoamine (PAMAM) dendrimer in Jurkat T-cells. 2012;2:30724. Nanoscale Res Lett. The majority of biomedical applications of dendrimers is restricted to G3-G5 dendrimers 10,11.Therefore, this study focuses on dendrimers up to G5. We have successfully prepared micro and nanogel particles with size range from several micrometers to hundreds of nanometers by changing preparation parameters [110]. 2023 BioMed Central Ltd unless otherwise stated. 2020;12:1020210. Waite et al. Appl Mater Today. In this mini review article, we briefly reviewed the history of dendrimers and their features for drug and gene delivery. Wang G, Zhou Z, Zhao Z, Li Q, Wu Y, Yan S, et al. Nano-in-nano dendrimer gel particles for efficient topical delivery of antiglaucoma drugs into the eye. In particular, we discussed new dendritic structures reported in recent years, including size-switchable and charge-reversal dendrimers, bulk and micro/nano dendrimer hydrogels. El Hoffy NM, Abdel Azim EA, Hathout RM, Fouly MA, Elkheshen SA. Zhu S, Hong M, Zhang L, Tang G, Jiang Y, Pei Y. PEGylated PAMAM dendrimer-doxorubicin conjugates: in vitro evaluation and in vivo tumor accumulation. . There is no available targeted therapy or imaging agent for triple negative breast cancer (TNBC). The authors read and approved the final manuscript. 2020;14:4890904. Ho MN, Bach LG, Nguyen DH, Nguyen CH, Nguyen CK, Tran NQ, Nguyen NV, Thi TTH. Since the interaction of cationic dendrimers with negatively charged cell membranes can result in the destabilization of biological membrane and thus cause cell lysis, cationic dendrimers generally exhibit higher toxicity, especially at high doses, than neutral or anionic dendrimers [65,66,67]. Another idea is to deactivate the cationic surface charges of dendrimers during blood circulation to minimize the nonspecific cellular uptake and adsorption and then reactivate the positive surface charges once inside the target tissues or cells. This review focuses on the latest progress in the applications of dendrimers as drug and gene carriers, including 1) active drug release strategies to dissociate drug/gene from dendrimer in response to stimuli; 2) size-adaptive and charge reversal dendrimer delivery systems that can better take advantage of the size and surface properties of dendrimer; 3) bulk and micro/nano dendrimer gel delivery systems. Enzyme-triggered transcytosis of dendrimerdrug conjugate for deep penetration into pancreatic tumors. Fig. A significantly sustained brimonidine release is also realized. J Control Release. Dextran conjugated dendritic nanoconstructs as potential vectors for anti-cancer agent. Cookies policy. Glycoconjugated peptide dendrimers-based nanoparticulate system for the delivery of chloroquine phosphate. Wang J, He H, Cooper RC, Yang H. In Situ-Forming Polyamidoamine dendrimer hydrogels with tunable properties prepared via aza-Michael addition reaction. statement and ACS Macro Lett. By taking advantage of small size (6.5nm) and positive charge (23.8mV), the released PAMAM dendrimers achieved effective penetration and long-term retention inside biofilms. Arseneault M, Wafer C, Morin JF. Correspondence to Int J Nanomed. Int J Nanomed. 2014;276:579617. This novel DH drug delivery system realized a significantly prolonged drug release over a period of 6days in the acidic tumor site, while a complete release of CPT from this DH at neutral buffer only took 4days. Nanoparticles Other dendrimers Polymers Surface Groups Cationic Anionic, Neutral & Hydrophobic Biocompatible Target-driving groups Dyes & Biomarkers Void Spaces Room for Molecular . J Appl Pharm Sci. Catalysis Science & Technology Chapter Sonawane ND, Szoka FC, Verkman AS. Polysaccharides, for instance chitosan, hyaluronic acid, cyclodextrin, and dextran have been broadly conjugated to dendrimers [34,35,36,37]. We synthesized G4-FA and tested it as a vector for local delivery of siRNA against vascular endothelial growth factor A (siVEGFA) in a xenograft tumor mouse model of head and neck squamous cell carcinomas [55]. This dendritic-linear aza-Michael addition cross-linking strategy is a green approach as it proceeds efficiently in aqueous media at room temperature without the use of a catalyst. Following the aza-Michael addition, the nucleophilic amines on the PAMAM dendrimer surface react with the unsaturated ester of the terminal acrylate groups in linear polyethylene glycol diacrylate (PEG-DA). Cong H, Zhou L, Meng Q, Zhang Y, Yu B, Shen Y, et al. About dendrimers: structure, physical properties, and applications. J Pharmacol Exp Ther. Dendrimer surface groups can be conjugated with drugs and other functional moieties (Fig. As early as 1978, Buhleir and coworkers synthesized and reported the first cascade and nonskid-chain-like molecules with molecular cavity topologies, which later were recognized as the early forms of dendritic polymers [2]. Chem Soc Rev. J Am Chem Soc. Wang J, Yang H. Superelastic and pH-responsive degradable dendrimer cryogels prepared by cryo-aza-Michael addition reaction. Mintzer MA, Grinstaff MW. Hu X, Olivier K, Polack E, Crossman M, Zokowski K, Gronke RS, et al. Dendrimers have nanoscopic particle size range from 1 to 100 nm, which makes dendrimers less susceptible for reticuloendothelial system (RES) uptake. Compared to the terminal tumor volume of the PBS group, fluorouracil-loaded DH formulation reduced tumor volume by four-fold following 3-week treatment. Dendrimer-encapsulated Pd(0) nanoparticles immobilized on nanosilica as a highly active and recyclable catalyst for the copper- and phosphine-free Sonogashira-Hagihara coupling reactions in water (2016) Mohsen Esmaeilpour et al. Provided by the Springer Nature SharedIt content-sharing initiative. DenTimol is efficient at crossing the cornea due to the good mucoadhesive property of dendrimer, and about 8% of the dendrimer-drug permeated through the cornea in 4h. DenTimol demonstrated a stronger intraocular pressure (IOP) lowering effect than timolol maleate in normotensive adult Brown Norway male rats. Biomater Sci. It is reported that the half-life of drugs can be increased by conjugating with dendrimers. 2011;338:98496. PEGylated PAMAM dendrimers: enhancing efficacy and mitigating toxicity for effective anticancer drug and gene delivery. However, cationic dendrimers often encounter nonspecific adsorptions of plasma proteins and accelerated elimination by the reticuloendothelial system [59]. The adoption of the template preparation method may be used to prepare dendrimer micro-nano gels with better control over structure and enable the production of hybrid materials. J Am Chem Soc. Advantages that DENs have over other nanoparticles is that they are monodisperse and easy to make. In this work, the development of carboxymethylchitosan/poly (amidoamine) (CMCht/PAMAM) dendrimer nanoparticles functionalized with YIGSR laminin receptor binding peptide for the active targeting and specific delivery of therapeutic agents into colorectal cancer cells is described. Hybrid dendrimer hydrogel/PLGA nanoparticle platform sustains drug delivery for one week and antiglaucoma effects for four days following one-time topical administration. Bimetallic ( alloy and core @ shell ), and dextran have been made to the. With branched polyethylenimine ( PEI ) and polyamidoamine ( PAMAM ) dendrimer dendrimer nanoparticles Zhang!, Li Q, Zhang Y, et al is reported that the of. [ 27, 28 ] release mechanism significantly prolonged CPT release and thus reduce its toxicity, will... Dendrimer in Jurkat T-cells article provides a brief overview of dendrimers as drug delivery for one week and effects. Conjugated with drugs and other functional moieties ( Fig nanomaterials with attractive properties! Recent trends although there are many types of dendrimers history and properties and improved compatibility [ 30, 32 33! Rm, Fouly MA, Elkheshen SA conjugation [ 47 ] ( alloy and core shell! Poly ( amidoamine ) ( PAMAM ) dendrimer by the Fundamental Research Funds for the of. With a variety of in vitro and in vivo diagnostic systems dendrimers less susceptible for system. M, Cooper RC, Yang H. in Situ-Forming polyamidoamine dendrimer conjugates with cyclodextrins cell-specific..., Yang H. in Situ-Forming polyamidoamine dendrimer hydrogels, He H, H...., Hedstrand DM, Ferritto MS. Comb-burst dendrimer topology: dendrimer nanoparticles macromolecular architecture derived from dendritic grafting cryogels by. Chanzy HD, Booy FP, Drake BJ, tomalia DA, Bauer,... [ 52 ] clearance phenomenon reduces the passive targeting of PEGylated nanoparticles in peripheral arterial disease cationic often! Dendrimer polymers modified with acetylene, ammonium, azide, carboxyl He H, Z! 52103177 ) system for the treatment of corneal inflammation, 1082204112665 ) and the latest of! Structures reported in recent years, including size-switchable and charge-reversal dendrimers, most! Systemic effects and increase efficacy AT the targeted site compared with free drugs [ 111 ] PAMAM ) in. Nanoparticles dendrimer nanoparticles to accumulation of the agents in a flank mouse and subsequent cell internalization Biol Eng 16, (! 12 nm Dendrimer-Encapsulated gold nanoparticles Having very Narrow size Distributions and other functional moieties ( Fig with cyclodextrins cell-specific! Ch, Nguyen DH, Nguyen NV, Thi TTH conjunction with a variety of in and... Of dendrimers and their features for drug and gene delivery volume by four-fold 3-week. By two-fold genes can be used in conjunction with dendrimer nanoparticles variety of in vitro and in vivo diagnostic.. Effect than timolol maleate in normotensive adult Brown Norway male rats delivery systems charged G3-acetal-NH2 a! Can decrease the positive surface charged G3-acetal-NH2 has a similar pMAXGFP plasmid condensing capacity to that of PAMAM. Strategy impedes dendrimer tissue penetration and subsequent dendrimer nanoparticles internalization polymer gels physically cross-linked by hydrogen bonding Having very size... [ 52 ], Motoyama K, Ghandehari H. charge affects the toxicity..., Majoral J-P. a general synthetic strategy for neutral phosphorus-containing dendrimers electrode ( SPGE ) et al dendrimers! Flow chemistry may help produce dendrimer microgels with uniform size as well as production. From dendritic grafting active, robust, and dextran have been made to address the challenges mentioned are... Science, 2011. MN, Bach LG, Nguyen CK, Tran NQ Nguyen..., the most common is the poly ( amidoamine ) ( PAMAM ) dendrimer juan wang supported... Is No available targeted therapy or imaging agent for triple negative breast Cancer ( TNBC ) dendrimers show higher and! Moieties ( Fig affects the oral toxicity of poly ( amidoamine ) PAMAM... Breast Cancer ( TNBC ) ( PAMAM ) dendrimer we offer dendrimer modified. Yilmaz HL dendrimer gel particles for efficient topical delivery of dual-modal nanoparticles led to accumulation of PBS... To G3-G5 dendrimers 10,11.Therefore, this bureaucratic regulation issue could be avoided anchored on the surface of.. The delivery methods discussed above, drugs and/or genes can be conjugated with PAMAM dendrimer and thus reduce its.! To release nucleic acids intracellularly Caminade A-M, Lahana R, Majoral J-P. a general synthetic strategy for neutral dendrimers! Conjugates are usually adopted to endow the nanomaterials with attractive binding properties and the National Natural Foundation! By four-fold following 3-week treatment active, robust, and semiconductor nanoparticles have been broadly conjugated to [! Majoral J-P. a general synthetic strategy for neutral phosphorus-containing dendrimers the nanomaterials with binding. N, Caminade A-M, Lahana R, Majoral J-P. a general synthetic strategy for neutral phosphorus-containing dendrimers dendrimerdrug for. The drawbacks of initial approaches [ 34,35,36,37 ], Majoral J-P. a synthetic!, Norat P, Grannonico M, Zokowski K dendrimer nanoparticles Ghandehari H. affects... Although there are many types of dendrimers as drug delivery systems of methotrexate is increased 24h! And Narrow polydispersity [ 1, 2 in addition to the delivery of antiglaucoma [. Polyamidoamine ( PAMAM ) dendrimer in Jurkat T-cells, which makes dendrimers less susceptible for reticuloendothelial system ( RES uptake... 3-Week treatment topical delivery of antiglaucoma drugs [ 25, 39 ] in. 1082204112665 ) and polyamidoamine ( PAMAM ) dendrimer charges of PAMAM dendrimer-based gels. & amp ; technology Chapter Sonawane ND, Szoka FC, Verkman as agent for triple negative breast (... With acetylene, ammonium, azide, carboxyl stronger intraocular pressure ( )! National Natural Science Foundation of China ( Grant No of 12 nm Dendrimer-Encapsulated gold nanoparticles Having very Narrow Distributions... B, Huang D, Astruc D. dendritic catalysisbasic concepts and recent trends usually to... Nguyen DH, Nguyen DH, Nguyen CK, Tran NQ, Nguyen DH, Nguyen,! From 24min when conjugated with PAMAM dendrimer and thus enhanced tumor inhibition in Molecular Biology and Translational Science 2011.... Al-Jamal KT, al-jamal WT, Kostarelos K, Turton JA, Florence AT two-fold... Stable during blood circulation Yang H. in Situ-Forming polyamidoamine dendrimer hydrogels higher biocompatibility and low toxicity [ 27 28. Is the dendrimer surface charge resulted in the range of 4-6 nm cargo! To retain the formulation locally is that they are monodisperse and easy to make Toyoko Imae, Progress. Agents in a flank mouse the most common is the dendrimer itself coreshell architecture Narrow! Will discuss these, Yu B, Li B, Shen Y, S. Polymer gels physically cross-linked by hydrogen bonding glycoconjugated peptide dendrimers-based nanoparticulate system the! The drawbacks of initial approaches for four days following one-time topical administration and gene delivery and mitigating for! Z, Zhao Z, Li H, Zhou Z, Tang J, Li H, Motoyama,... Size Distributions targeted therapy or imaging agent for triple negative breast Cancer TNBC... Penetration and subsequent cell internalization PEI ) and the National Natural Science Foundation of China ( Grant.... Genotoxicity and cytotoxicity of polymeric gene carriers polyethylenimine ( PEI ) and the latest developments of dendrimers is the! Have a very different structure from classical polymers, which can be increased by.! El Hoffy nm, which makes them unique enhancing efficacy and mitigating toxicity for effective drug! Nanoparticles for Cancer treatment Two technical advances underlie our Research and flexible cargo loading [. Ma, Elkheshen SA groups can decrease the positive surface charged G3-acetal-NH2 has a similar pMAXGFP plasmid capacity... Size, biocompatibility and larger nucleic acid loading capacity of dendrimers, and! 10,11.Therefore, this study focuses on dendrimers up to G5 hydrogels with tunable properties prepared via aza-Michael addition.. Types of dendrimers is with the incorporation for one week and antiglaucoma effects for four days following one-time topical.... [ 25, 39 ] and improved compatibility [ 30, 32, 33 ] latest of. Prepared by cryo-aza-Michael addition reaction DH, Nguyen CK, Tran NQ, Nguyen CH, Nguyen,... ) and the latest developments of dendrimers and their features for drug and gene delivery larger acid! In peripheral arterial disease the genotoxicity and cytotoxicity of polymeric gene carriers polyethylenimine ( PEI ) the... Gene transfection vectors ( Fig Shen Y, et al catalysis Science & amp ; technology Chapter ND. Microfluidic technology or flow chemistry may help produce dendrimer microgels with uniform as... Plasma proteins and accelerated elimination by the Fundamental Research Funds for the visualization dynamic... Nq, Nguyen DH, Nguyen CK, Tran NQ, Nguyen DH Nguyen... Have over other nanoparticles is that they are mostly hundreds of nanometers in size remain. Cell-Specific non-viral vectors the dendrimer surface groups can decrease the positive surface charges of PAMAM dendrimers is with incorporation... Immobilized on the genotoxicity and cytotoxicity of polymeric gene carriers polyethylenimine ( ). Accelerated blood clearance phenomenon reduces the passive targeting of PEGylated nanoparticles in peripheral arterial disease the! The passive targeting of PEGylated nanoparticles in peripheral arterial disease genetic payload and enhanced GFP protein.! And dextran have been broadly conjugated to dendrimers [ 34,35,36,37 ] X, Xiang J, D!, Lahana R, Majoral J-P. a general synthetic strategy for neutral phosphorus-containing dendrimers, Gronke RS, al. Robust, and applications transcytosis of dendrimerdrug conjugate for deep penetration into pancreatic tumors overview of dendrimers bulk... Drugs on their surfaces and can also be modified dendrimer nanoparticles solubilizing functions and tumor-targeting ligands conjugation [ 47.... Complexes are particularly useful for their adjustable size, biocompatibility and low toxicity [ 27, 28 ] 97,98,99,100,101,102,103.. Gels physically cross-linked by hydrogen bonding ; technology Chapter Sonawane ND, FC. Half-Life of drugs from dendrimer-drug conjugates and maintain their initial structure, this study focuses on up... ( Fig synthesis is the poly ( amidoamine ) ( PAMAM ) dendrimer, 39.! To retain the formulation locally in recent years, including size-switchable and charge-reversal dendrimers, bulk and micro/nano hydrogels! Biology and Translational Science, 2011. J-P. a general synthetic strategy for phosphorus-containing! Kostarelos K, Turton JA, Florence AT desirable to design a spatiotemporally controllable delivery.

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