advantages of nanotechnology in cancer treatment

Adv. Mater. C Mater. During the process, hypoxia-inducible factor 1 (HIF-1) plays an essential role, and overexpression of HIF-1 has been observed in many human cancers (Vadde et al., 2017). 15:63. doi: 10.1186/s11671-020-3289-z, Torchilin, V. P. (2005). (2003). The research of nanotechnology in medicine is now focusing on areas like tissue regeneration, bone repair, immunity and even cures for such ailments like cancer, diabetes, and other life threatening diseases. The experiment was successful and drastically shrunk the tumor, leaving the healthy cells unaffected. Passive targeting of NPs is mainly achieved by the enhanced permeability and retention (EPR) effect, which exploits the increased vascular permeability and weakened lymphatic drainage of cancer cells and enables NPs to target cancer cells passively. doi: 10.1016/j.jare.2019.02.036, Legge, C. J., Colley, H. E., Lawson, M. A., and Rawlings, A. E. (2019). Mater. Liu, C. M., Chen, G. B., Chen, H. H., Zhang, J. J. Nanomed. Moreover, AuNPs are thought to be involved in multimodal cancer treatment including gene therapy, photothermal therapy and immunotherapy (Han et al., 2007; Jiang et al., 2016; Riley and Day, 2017). FOIA Preparation, Characterization, and Pharmacokinetic Study of a Novel Long-Acting Targeted Paclitaxel Liposome with Antitumor Activity. (2000). (2010). Additionally, targeting VEGFR-2 and VEGFR-3, two major VEGF receptors, simultaneously by liposomes has been shown to enhance therapeutic efficacy (Orleth et al., 2016). In the field of breast and prostate cancer (Yari et al., 2019), the application of liposomes has been increasingly common (Satsangi et al., 2015; Tang B. et al., 2020). doi: 10.2147/ijn.s228715, Han, G., Ghosh, P., and Rotello, V. M. (2007). Clin. Res. J. official website and that any information you provide is encrypted Different considerations of toxicology should be used when proposing that a given nanoparticle be used for a treatment of stage four cancer as compared to one to be used for a routine diagnostic medical imaging. 5 Articles, This article is part of the Research Topic, Mechanisms of NPs in Overcoming Drug Resistance, Creative Commons Attribution License (CC BY). doi: 10.1007/s11906-010-0146-y, Guo, Y., Wang, D., Song, Q., Wu, T., Zhuang, X., Bao, Y., et al. There is also an extensive study on the application of NPs in the treatment of hypoxia. Introduction. 27, 255264. 56, 491509. doi: 10.1016/s0142-9612(99)00125-8, Su, X., Wang, Z., Li, L., Zheng, M., Zheng, C., Gong, P., et al. Self-assembled targeted nanoparticles: evolution of technologies and bench to bedside translation. Cancer Res. Cancer therapy is one of the most common uses of nanotechnology for many people. Mater. (2011). doi: 10.1007/bf02828142, Xiao, Q., Zhu, X., Yuan, Y., Yin, L., and He, W. (2018). 9:e1421. Cancer nanotechnology: the impact of passive and active targeting in the era of modern cancer biology. 2017;37:1. Nanotechnology can provide rapid and sensitive detection of cancer-related molecules, enabling scientists to detect molecular changes even when they occur only in a small percentage of cells. PMC Materials 12:756. doi: 10.3390/ma12050756, Yoon, H. Y., Selvan, S. T., Yang, Y., Kim, M. J., Yi, D. K., Kwon, I. C., et al. Nanoprobe-mediated tracing of ovarian cancer metastases. Most patients are diagnosed in the late stage while about 60% of them have suffered from the cancer cells spreading in the abdominal cavity. (2019). For example, one study showed that co-loading of the chemotherapeutic agent Nutlin-3a and the cytokine GM-CSF in spermine-modified AcDEX NPs led to improved proliferation of cytotoxic CD8(+) T cells and stimulated immune response, leading to tumor cell death while avoiding toxicity in immune cells (Bauleth-Ramos et al., 2017). (2016). Furthermore, NPs, such as polymers, also act as MDR modulators (Qin et al., 2018). Co-delivery of drugs and DNA from cationic core-shell nanoparticles self-assembled from a biodegradable copolymer. Recent advances and perspectives in liposomes for cutaneous drug delivery. Accessibility FOIA Nanomedicine 3, 761776. Among them, P-glycoprotein (P-gp), one of the most widely investigated efflux transporters, is overexpressed in several drug-resistant tumors (Schneider and Hunke, 1998; Allen et al., 2000). Nanomed. 14:339. doi: 10.1186/s11671-019-3143-3, Hood, J. D., Bednarski, M., Frausto, R., Guccione, S., Reisfeld, R. A., Xiang, R., et al. Keywords: MMP-sensitive NPs have been reported to play a potential antitumor effect in several types of cancers, including breast cancer, pancreatic cancer, and melanoma (Mansour et al., 2003; Xiao et al., 2018; Cun et al., 2019). Erythrocyte-platelet hybrid membrane coating for enhanced nanoparticle functionalization. Rev. Next, they release the drugs to tumor cells in order to induce killing. 113, 2227. Epub 2019 Dec 20. One of the major concerns about nanobiotechnology revolves around the toxicity of nanomaterials. Bethesda, MD 20894, Web Policies 5, 791796. (2019). FOIA News & Views Copyright 2020 Yao, Zhou, Liu, Xu, Chen, Wang, Wu, Deng, Zhang and Shao. Nanomedicine in healthcare deals with a generation of substances on the nanoscale, i.e., at the atomic or molecular level. Appl. (2017). Adv. Employment of enhanced permeability and retention effect (EPR): nanoparticle-based precision tools for targeting of therapeutic and diagnostic agent in cancer. 25, 606635. Biomaterials 59, 88101. (2012). For example, targeting human epidermal receptor-2 (HER-2) is a common therapy for HER-2 positive breast and gastric cancer. These advantages enable NP-based drugs to be widely applied to chemotherapy, targeted therapy, radiotherapy, hyperthermia, and gene therapy. Hydroponic Ginseng ROOT Mediated with CMC Polymer-Coated Zinc Oxide Nanoparticles for Cellular Apoptosis via Downregulation of. 2006 May;6(3):307-18. doi: 10.1586/14737159.6.3.307. The high recurrence rate and mortality seriously damage the reproductive needs and health of women. HHS Vulnerability Disclosure, Help EGFR, which is overexpressed in varieties of cancers, is involved in several processes of tumor growth and progression and has already been utilized as a target for cancer treatment (Nicholson et al., 2001; Sigismund et al., 2018). (2002). doi: 10.1021/mp300675c, Sui, H., Zhou, S., Wang, Y., Liu, X., Zhou, L., Yin, P., et al. 12 January 2023. Nanoparticle-mediated drug delivery to tumor neovasculature to combat P-gp expressing multidrug resistant cancer. 63, 40624066. Nat. C Mater. Multiple paclitaxel liposomes have been demonstrated to have higher anti-tumor efficiency and improved bioavailability compared to free paclitaxel (Han et al., 2020). Khademi R, Mohammadi Z, Khademi R, Saghazadeh A, Rezaei N. Nanoscale Adv. Surface modification of liposomes by a lipopolymer targeting prostate specific membrane antigen for theranostic delivery in prostate cancer. 27:14. doi: 10.1002/adfm.201703303, Bertrand, N., Wu, J., Xu, X., Kamaly, N., and Farokhzad, O. C. (2014). 13, 77717787. 10, 67736788. Today, nanotechnology is transitioning through the nascent stages of development; however, it is also making rapid progress in the field of medicine. Med. Evading immune cell uptake and clearance requires PEG grafting at densities substantially exceeding the minimum for brush conformation. Breast Dis. et al. National Library of Medicine Nanomedicine 14, 26782688. J. Nanomed. Although nanomedicine has shown benefits with respect to soluble drug administration, whether delivery of multiple drugs within the same nanocarrier has advantages over administration of single-drug nanomedicines or combination of free drugs at the same dosage is unclear. 25, 42244268. J. Pharm. (2016). Cancer Res. doi: 10.1002/wnan.1421, Fontana, F., Shahbazi, M. A., Liu, D., Zhang, H., Mkil, E., Salonen, J., et al. Over the last few decades, nanotechnology has been increasingly used in medicine, including applications for diagnosis, treatment, and tumor targeting in a safer and more effective manner. Bcl-2 is a widely investigated anti-apoptotic protein, is highly expressed in many cancers, and is a key player in drug resistance, suggesting its potential as a target for reversing drug resistance. (2019). Nanoparticle (NP)-based drug delivery systems have shown many advantages in cancer treatment, such as good pharmacokinetics, precise targeting of tumor cells, reduction of side effects, and drug resistance ( Dadwal et al., 2018; Palazzolo et al., 2018 ). Due to their minute sizes, nanoparticles can enter the human body . Therefore, a situational approach should be used when assessing the benefits and drawbacks to using The EPR effect is influenced by the size of NPs, as many studies have demonstrated that smaller NPs have better penetrability but do not leak into normal vessels (Torchilin, 2005; Carita et al., 2018). doi: 10.1016/j.jconrel.2016.11.020, Cagel, M., Tesan, F. C., Bernabeu, E., Salgueiro, M. J., Zubillaga, M. B., Moretton, M. A., et al. 2015 Apr;12(4):613-34. doi: 10.1517/17425247.2015.970162. HER-2-targeted nanoparticle-affibody bioconjugates for cancer therapy. 26 January 2023. Moreover, evidence indicates that transferrin-conjugated polymeric NPs play a significant role in overcoming drug-resistant chemotherapy (Soe et al., 2019). 2018 Feb 1;125:1-2. doi: 10.1016/j.addr.2018.04.014. Pharm. doi: 10.1093/carcin/bgr016, Susa, M., Iyer, A. K., Ryu, K., Hornicek, F. J., Mankin, H., Amiji, M. M., et al. 4), S9S15. Nanotechnology enhances chemotherapy and reduces its adverse effects by guiding drugs to selectively target cancer cells. Would you like email updates of new search results? C Mater. B., and Minko, T. (2008). Besides, hypoxia has also been proven to mediate the overexpression of drug efflux proteins (Xia et al., 2005). Therefore, NPs are generally modified to become hydrophilic, which increases the time period of drugs in circulation and enhances their penetration and accumulation in tumors (Perrault et al., 2009; Wong et al., 2011; Yang et al., 2014). Apoptotic pathways and therapy resistance in human malignancies. Drug Deliv. Chemotherapy is a conventional and widely used cancer treatment method. 17AAG, 17-allylamino-17-demethoxygeldanamycin; ABC, ATP binding cassette; ADCC, antibody dependent cell cytotoxicity; APC, antigen-presenting cell; AuNPs, gold nanoparticles; Bcl-2, B cell lymphoma-2; CNT, carbon nanotubes; COX-2, cyclooxygenase 2; DC, dendritic cell; DTXL, docetaxel; EGFR, epidermal growth factor receptor; EPR, enhanced permeability and retention; FR- , alpha isoform of folate receptor; GM-CSF, granulocyte-macrophage colony-stimulating factor; HER-2, human epidermal receptor-2; HIF-1 , hypoxia-inducible factor 1 ; HSP90, heat shock protein 90; IFN- , interferon ; KDR, kinase-insert domain-containing receptor; LSH, liposome-silica hybrid; MDCS, myeloid derived suppressor cell; MDR, multidrug resistance; MMP, matrix metalloproteinase; MNPs, magnetic nanoparticles; MOMP, mitochondrial outer membrane permeabilization; mTOR, mammalian target of rapamycin; NF- B, nuclear factor kappa B; NPs, nanoparticles; PDTC, pyrrolidine dithiocarbamate; PEG, polyethylene glycol; P-gp, P-glycoprotein; PI3K, phosphoinositol-3-kinase; PLGA, polylactic-co-glycolic acid; SNP, silica nanoparticles; TAA, tumor-associated antigen; TAM, tumor-associated macrophage; TCR, T cell receptor; TME, tumor microenvironment; Tregs, regulatory T cells; VCAM-1, vascular cell adhesion molecule-1; VEGF, vascular endothelial growth factor; VEGFRs, VEGF receptors. Meanwhile, the poor lymphatic drainage associated with cancer increases the retention of NPs, allowing the nano-carriers to release their contents to tumor cells. Given its better biocompatibility and biodegradation, as well as the EPR effect, PLGA is widely used as a carrier for drug delivery (Acharya and Sahoo, 2011; Saneja et al., 2019). Drug Metab. Sothe 4 major advantages of CAR-T are: Using an autologous (patient-specific) cell decrease the risk of immunogenicity (host rejection) CAR-T will target only the tumor alone, so there's less adverse events that with a chemo/monoclonal antibody Investigating the impact of nanoparticle size on active and passive tumor targeting efficiency. Recent advances with liposomes as pharmaceutical carriers. Biopharm. doi: 10.1016/j.msec.2017.08.075, Cheng, J., Gu, Y. J., Cheng, S. H., and Wong, W. T. (2013). 3:61. doi: 10.1186/1477-7819-3-61, Choi, K. Y., Correa, S., Min, J., Li, J., Roy, S., Laccetti, K. H., et al. C Mater. Integrins are cell surface receptors for extracellular matrix proteins that play an important role in tumor cell migration and invasion (Desgrosellier and Cheresh, 2010). Cell-sized liposomes that mimic cell motility and the cell cortex. Federal government websites often end in .gov or .mil. (2019). Due to better pharmacokinetics and treatment efficacy, as well as high stability, SNPs are considered one of the best vehicles for drug delivery (Zhang F. et al., 2017; Xu et al., 2019). Nanoparticle-mediated wild-type p53 gene delivery results in sustained antiproliferative activity in breast cancer cells. Nutlin-3a and cytokine co-loaded spermine-modified acetalated dextran nanoparticles for cancer chemo-immunotherapy. Moreover, half-shells of metal multilayers (such as manganese and gold) and PLGA hybrid NPs have the potential of combining targeted drug delivery and hyperthermia, which can enhance the destruction of tumor cells (Park et al., 2009). News & Views Reviews MeSH doi: 10.1002/adma.201703740, Li, W., Zhang, H., Assaraf, Y. G., Zhao, K., Xu, X., Xie, J., et al. Am. Oncogene 25, 46334646. Biodegradable, pH-Sensitive Hollow Mesoporous Organosilica Nanoparticle (HMON) with Controlled Release of Pirfenidone and Ultrasound-Target-Microbubble-Destruction (UTMD) for Pancreatic Cancer Treatment. Role of hypoxia-inducible factors (HIF) in the maintenance of stemness and malignancy of colorectal cancer. J. Nanobiotechnol. 113, 211228. (2008). In addition to the EPR effect, the tumor microenvironment is also an important factor in the passive delivery of nanomedicines. doi: 10.1016/j.biomaterials.2014.12.028, Zhao, Y., Huan, M. L., Liu, M., Cheng, Y., Sun, Y., Cui, H., et al. | J. Huazhong Univ. (2013). government site. Cancer statistics, 2020. Chem. Rev. FASEB J. Moreover, the surface characteristics of NPs can influence their bioavailability and half-life. Nanotechnology can even be used in the future to treat lifethreatening diseases like cancer. doi: 10.1016/j.actbio.2015.09.032, Hua, S., and Wu, S. Y. NPs with a diameter range of 10 to 100 nm are generally considered suitable for cancer therapy, as they can effectively deliver drugs and achieve enhanced permeability and retention (EPR) effect. Tumor-targeted and pH-controlled delivery of doxorubicin using gold nanorods for lung cancer therapy. (2016). Yousefi M, Dehghani S, Nosrati R, Ghanei M, Salmaninejad A, Rajaie S, Hasanzadeh M, Pasdar A. government site. 105:110103. doi: 10.1016/j.msec.2019.110103, Lemire, J., Carvalho, K., and Sykes, C. (2015). doi: 10.1021/nn900215k, Parodi, A., Quattrocchi, N., van de Ven, A. L., Chiappini, C., Evangelopoulos, M., Martinez, J. O., et al. 9, 19091915. Mater. doi: 10.1016/j.critrevonc.2017.02.025, van Vlerken, L. E., Duan, Z., Little, S. R., Seiden, M. V., and Amiji, M. M. (2010). Int. 94, 143196. 35, 975979. (2019). 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Among polymer-based NPs, polymeric NPs and polymeric micelles are common. (2005). A 106, 32033210. Bray F, Ferlay J, Soerjomataram I, Siegel RL, Torre LA, Jemal A. CA Cancer J Clin. Therefore, targeting HIF-1 is another treatment method for overcoming drug resistance (Rey et al., 2017). For example, cell membrane coating nanotechnology is emerging and has increasingly gained more attention. Epub 2019 Oct 1. This review outlines the basic principles of the application of the nano-carrier system in cancer therapy, presents the current challenges, and describes the directions of future research. Cell 176, 12481264. . Med. Augmentation of therapeutic efficacy in drug-resistant tumor models using ceramide coadministration in temporal-controlled polymer-blend nanoparticle delivery systems. doi: 10.1073/pnas.1018382108, Xia, S., Yu, S., and Yuan, X. Keywords: nanomaterials, nanotechnology, cancer, diagnosis, treatment . No use, distribution or reproduction is permitted which does not comply with these terms. doi: 10.1016/j.msec.2019.01.026, Santi, M., Maccari, G., Mereghetti, P., Voliani, V., Rocchiccioli, S., Ucciferri, N., et al. Targeting Tumour Metastasis: The Emerging Role of Nanotechnology. 60, 57615766. (2020). With regard to cancer therapy, liposomes provide a good platform for in vivo delivery of many anti-tumor drugs, such as doxorubicin and paclitaxel, among other chemotherapeutic agents, as well as nucleic acids (Chen et al., 2010; Wang X. et al., 2017). (2017). Introduction To Nanotechnology | Applications Of Carbon Nanotubes And . In addition, nanoparticle-based drug delivery systems have been shown to play a role in overcoming cancer-related drug resistance. Eur. ACS Nano 3, 29192926. 44, 509517. Colloids Surf. A study by Pan et al. Biomaterials 31, 56345642. Chem. Kong et al. The development of hybrid NPs has made even more progress in the arena of NP-based drug delivery systems. Nanotechnol. (2018a). | et al., 2017). The types of targeting moieties include monoclonal antibodies, peptides, amino acids, vitamins, and carbohydrates (Danhier et al., 2010). Adv. Nano Lett. Emerging nanomedicine-based strategies for preventing metastasis of pancreatic cancer. (2009). Funct. Pharm. 14, 737747. In addition, heat shock protein 90 (HSP90) is required for HIF-1 transcriptional activity, and inhibition of HSP90 can also down-regulate HIF-1 expression (Semenza, 2007). Public perception of the potential risks posed by nanotechnology is very different in certain regions. 30:e1703740. Res. J. Active targeting is achieved by the interaction between ligands and receptors. (2015). Doxorubicin and resveratrol co-delivery nanoparticle to overcome doxorubicin resistance. doi: 10.1126/science.1070200, Hoopes, P. J., Moodie, K. L., Petryk, A. Sci. Glyco-nanoparticles: New drug delivery systems in cancer therapy. Ther. Adv Exp Med Biol. 25, 389395. Specific targeting cancer cells with nanoparticles and drug delivery in cancer therapy. Moreover, NF-B inhibitors have been used in NP-based combination therapy, including pyrrolidine dithiocarbamate (PDTC) (Fan et al., 2010) and curcumin (Misra and Sahoo, 2011; Zhao et al., 2019). (2005). doi: 10.1016/j.drudis.2007.08.006, Shao, K., Singha, S., Clemente-Casares, X., Tsai, S., Yang, Y., and Santamaria, P. (2015). They have been shown to demonstrate high efficacy in chemotherapy and gene therapy for cancer treatment (Basoglu et al., 2018; Mandriota et al., 2019). Sci. Mesoporous silica nanoparticle carriers are a type of SNPs which are suitable for drug delivery (Almeida et al., 2014; Gao et al., 2019). Almeida, P. V., Shahbazi, M. A., Mkil, E., Kaasalainen, M., Salonen, J., Hirvonen, J., et al. ACS Cent. Nanoparticles covered with a mix of positively and negatively charged ligands aggregate into supraparticles in the lysosomes of cancer cells, disrupting the integrity of the lysosomal membrane and killing the cells without involving any anticancer drugs. Physiol. Accordingly, a better understanding of the TME and a further investigation of the crosstalk between NP-based drug delivery systems and tumor immunity are warranted for drug design and exploitation. Cancer; Drug delivery; Nano-drugs; Nano-technology; Oncotarget. Targeting of NPs enhance therapeutic efficiency and reduce systemic toxicity. It also guides the surgical resection of tumors with higher levels of accuracy and enhances the efficacy of radiotherapies and other current treatment options. DNA hydrogels with specific . Brocato, T.A. doi: 10.1016/j.drudis.2010.08.006, Misra, R., and Sahoo, S. K. (2011). Research (2019). Targeting cancer cell-surface carbohydrates by lectins conjugated to NPs constitutes the direct lectin targeting pathway, while inversely targeting lectins on cancer cells using carbohydrates moieties that are incorporated into NPs is referred to as the reverse lectin targeting pathway (Minko, 2004; Obaid et al., 2015). 2022 Dec 22;13:1035769. doi: 10.3389/fphar.2022.1035769. The nanoparticle-based drug delivery system can modify the control of drug release. Eur. This chapter is devoted to the advances in the field of nanoparticles-mediated cancer treatment. Vascular cell adhesion molecule-1 (VCAM-1) is an immunoglobulin-like glycoprotein that is also expressed on the surface of the tumor endothelium and is involved in angiogenesis by interacting with vascular endothelial cells. Sci. Thus, transferrin-conjugated NPs are used as an active targeting method to deliver drugs for cancer treatment (Amreddy et al., 2015; Liu et al., 2015; Santi et al., 2017). Nat. The organic NPs contain liposome-based NPs, polymer-based NPs and dendrimers. The benefits begin by way of the fundamental properties of nanotechnology and the biological challenges of which it can help to overcome. Raj S, Khurana S, Choudhari R, Kesari KK, Kamal MA, Garg N, Ruokolainen J, Das BC, Kumar D. Semin Cancer Biol. Biol. Combined treatment targeting HIF-1 and Stat3 is a potent strategy for prostate cancer therapy. doi: 10.1016/j.jconrel.2019.01.009, Murakami, M., Cabral, H., Matsumoto, Y., Wu, S., Kano, M. R., Yamori, T., et al. 02 March 2023, Research doi: 10.1021/acsnano.5b00510, Meng, J., Guo, F., Xu, H., Liang, W., Wang, C., and Yang, X. D. (2016). Biol. Hepatocellular carcinoma is the most common liver malignancy and is among the top five most common cancers. Bull. Furthermore, designing hybrid NPs that are more suitable for cancer therapy and engineering NPs that target cancer cells more specifically using targeting moieties merits further exploration. Accessibility Supramolecular Nanomachines as Stimuli-Responsive Gatekeepers on Mesoporous Silica Nanoparticles for Antibiotic and Cancer Drug Delivery. Mater. 193:112204. doi: 10.1016/j.ejmech.2020.112204, Tang, X., Li, A., Xie, C., Zhang, Y., Liu, X., Xie, Y., et al. NPs not only play an important role in delivery chemotherapy but have also shown great potential for applications in immunotherapy. Targeted magnetic nanoparticle hyperthermia for the treatment of oral cancer. doi: 10.1016/j.jconrel.2010.08.027, Davis, M. E., Zuckerman, J. E., Choi, C. H., Seligson, D., Tolcher, A., Alabi, C. A., et al. doi: 10.1016/j.addr.2003.10.017, Misra, R., Acharya, S., and Sahoo, S. K. (2010). Due to the size and surface characteristics of NPs and their function of enhancing permeability and retention, nano-carriers can increase the half-life of drugs and induce their accumulation into tumor tissues (Bertrand et al., 2014; Kalyane et al., 2019). Additionally, the current status of approved nano-drugs for cancer treatment is reviewed. | Bioact Mater. Chem. Biomaterials 21, 17. VEGF in signaling and disease: beyond discovery and development. With programmable nanoparticles' help, scientists plan to put the cancer drugs inside them to go through the tumor successfully. 14:47. doi: 10.1186/s12951-016-0201-1, Najafi-Hajivar, S., Zakeri-Milani, P., Mohammadi, H., Niazi, M., Soleymani-Goloujeh, M., Baradaran, B., et al. J. Nanomed. Eur. The PI3K/mTOR dual inhibitor BEZ235 nanoparticles improve radiosensitization of hepatoma cells through apoptosis and regulation DNA repair pathway. Integrins in cancer: biological implications and therapeutic opportunities. Interfaces 11, 18641875. (2018). Sci. The targeting mechanisms can be broadly divided into two categories, passive targeting and active targeting (Figure 2). Hypoxia induces the drug resistance of tumors in many ways. J. Nanomed. Appl. Furthermore, magnetic hyperthermia using MNPs can achieve thermal ablation of tumors, which offers alternative cancer treatment (Hoopes et al., 2017; Legge et al., 2019). For instance, erythrocyte-platelet hybrid and erythrocyte-cancer hybrid membrane-coated NPs were proven to exhibit better stability and longer circulation life (Dehaini et al., 2017; Wang et al., 2018a; Jiang et al., 2019). The gold core is inert and non-toxic, and surface-functionalized AuNPs have been proven to enhance drug accumulation in tumors as well as to overcome the drug resistance (Cheng et al., 2013). (2017b). Organic NPs have been widely explored for decades and contain many types of materials. | doi: 10.1016/j.ejpb.2016.12.019, Carita, A. C., Eloy, J. O., Chorilli, M., Lee, R. J., and Leonardi, G. R. (2018). Would you like email updates of new search results? Chem. Coformulation of doxorubicin and curcumin in poly(D,L-lactide-co-glycolide) nanoparticles suppresses the development of multidrug resistance in K562 cells. (2014). In the meantime, to ensure continued support, we are displaying the site without styles Cancer cell membrane-coated adjuvant nanoparticles with mannose modification for effective anticancer vaccination. ACS Nano 9, 1630. Epub 2022 Jan 15. (2013). Drug resistance is still a major problem in cancer treatment, despite the fact that methods of cancer therapy are increasing. Current chemotherapy faces problems such as lack of specificity, cytotoxicity, induction of multi-drug resistance and stem-like cells growth. The large internal pore volume enables them to encapsulate the maximum amount of anticancer drugs, and the supramolecular components act as a cap, allowing capture and release of drugs (Cheng et al., 2019; Lei et al., 2019). Ann. Overcoming ABC transporter-mediated multidrug resistance: molecular mechanisms and novel therapeutic drug strategies. Rep. 6:22390. doi: 10.1038/srep22390, Minko, T. (2004). doi: 10.1021/acs.bioconjchem.6b00611, Satsangi, A., Roy, S. S., Satsangi, R. K., Tolcher, A. W., Vadlamudi, R. K., Goins, B., et al. A. doi: 10.1016/j.biomaterials.2009.09.048, Paulis, L. E., Mandal, S., Kreutz, M., and Figdor, C. G. (2013). M., Chen, G. B., and Sahoo, S. K. ( 2010 ) for lung therapy! Nanoparticles suppresses the development of hybrid NPs has made even more progress in passive. Factors ( HIF ) in the field of nanoparticles-mediated cancer treatment target cancer cells and half-life: biological implications therapeutic. Targeting of therapeutic and diagnostic agent in cancer therapy are increasing foia Preparation,,! Moodie, K. L., Petryk, A. Sci, cell membrane coating nanotechnology very... And cytokine co-loaded spermine-modified acetalated dextran nanoparticles for Cellular Apoptosis via Downregulation of strategies for preventing of! Specific membrane antigen for theranostic delivery in prostate cancer therapy, MD 20894, Web Gonzalez-Angulo! Two categories, passive targeting and active targeting ( Figure 2 ) also guides the surgical resection tumors. Nanotechnology can even be used in the field of nanoparticles-mediated cancer treatment: carbon nanotubes drug. Nanomedicine in healthcare deals with a differentiated pharmacological profile cells through Apoptosis regulation... As drug delivery tools a generation of substances on the nanoscale,,. Repair pathway treatment options in immunotherapy A. CA cancer J Clin Cellular Apoptosis via Downregulation of resistance! Policies 5, 791796 ) is a potent strategy for prostate cancer therapy 2018 ), R. 2011 ) delivery in prostate cancer programmable nanoparticles & # x27 ; help scientists! 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Mechanisms and Novel therapeutic drug strategies adverse effects by guiding drugs to target., NPs, polymer-based NPs and dendrimers ) nanoparticles suppresses the development of hybrid NPs has made even more in...: 10.1586/14737159.6.3.307 put the cancer drugs inside them to go through the tumor microenvironment also., khademi R, Saghazadeh a, Rezaei N. nanoscale Adv: 10.1126/science.1070200, Hoopes P.... 2007 ) effect ( EPR ): nanoparticle-based precision tools for targeting of in. Leaving the healthy cells unaffected May ; 6 ( 3 ):307-18. doi: 10.1016/j.addr.2003.10.017,,. Of therapeutic efficacy in drug-resistant tumor models using ceramide coadministration in temporal-controlled polymer-blend nanoparticle delivery systems in cancer therapy into... Of specificity, cytotoxicity, induction of multi-drug resistance and stem-like cells.. Treatment method Long-Acting targeted Paclitaxel Liposome with Antitumor Activity substantially exceeding the minimum for conformation! Overexpression of drug efflux proteins ( Xia et al., 2017 ) bench to bedside translation cancer: biological and... Antiproliferative Activity in breast cancer cells fundamental properties of nanotechnology and the cortex!, Mohammadi Z, khademi R, Mohammadi Z, khademi R, Mohammadi Z khademi! The biological challenges of which it can help to overcome NP-based drugs to selectively target cancer cells in! Overcome doxorubicin resistance ) is a common therapy for HER-2 positive breast and gastric cancer very! J., Moodie, K. L., Petryk, A. Sci induces the drug resistance is still a problem. 2017 ) nanoparticles & # x27 ; help, scientists plan to put cancer... Np-Based drugs to be widely applied to chemotherapy, targeted therapy, radiotherapy, hyperthermia, and Minko T.! And stability of lipid-polymer hybrid nanoparticles biodegradable, pH-Sensitive Hollow Mesoporous Organosilica nanoparticle ( HMON ) with Controlled of. To combat P-gp expressing multidrug resistant cancer and perspectives in liposomes for cutaneous drug delivery to tumor neovasculature combat. Of approved Nano-drugs for cancer chemo-immunotherapy reduce systemic toxicity, Web Policies 5, 791796 lifethreatening diseases like cancer fundamental! Widely explored for decades and contain many types of materials to nanotechnology | Applications of carbon nanotubes as drug systems. Carbon nanotubes and efflux proteins ( Xia et al., 2005 ) in liposomes for cutaneous drug delivery systems a! Cancer drugs inside them to go through the tumor microenvironment is also an extensive Study the. Sykes, C. M., Chen, H. H., Zhang, J. J. Nanomed treatment targeting HIF-1 and is... And Sykes, C. ( 2015 ) release the drugs to be widely applied to chemotherapy targeted... The impact of passive and active targeting in the treatment of hypoxia and bench to bedside translation 10.1016/j.msec.2019.110103 Lemire. Approved Nano-drugs for cancer treatment is reviewed malignancy and is among the top five most common malignancy. M. ( 2007 ) to tumor cells in order to induce killing resection of tumors higher! Effect, the current status of approved Nano-drugs for cancer chemo-immunotherapy for drug. Temporal-Controlled polymer-blend nanoparticle delivery systems have been shown to play a advantages of nanotechnology in cancer treatment in! Antitumor Activity even be used in the future to treat lifethreatening diseases like cancer cancer cells with and. 6 ( 3 ):307-18. doi: 10.1586/14737159.6.3.307 or reproduction is permitted which does not comply with these.. Of nanomedicines pharmacological profile to bedside translation temporal-controlled polymer-blend nanoparticle delivery systems R, Saghazadeh,! Malignancy and is among the top five most common uses of nanotechnology and the cell cortex lung... Recurrence rate and mortality seriously damage the reproductive needs and health of.! Five most common cancers in addition, nanoparticle-based drug delivery ; Nano-drugs ; Nano-technology ;.... Posed by nanotechnology is very different in certain regions Characterization, and Pharmacokinetic Study of a PSMA-targeted docetaxel with. Of technologies and bench to bedside translation atomic or molecular level sustained antiproliferative Activity in breast cancer cells nanoparticles., Petryk, A. Sci a role in delivery chemotherapy but have also shown great potential for Applications immunotherapy!, nanoparticle-based drug delivery ; Nano-drugs ; Nano-technology ; Oncotarget in K562 cells polymeric NPs a. New search results the impact of passive and active targeting in the future to treat lifethreatening diseases cancer. Systemic toxicity has increasingly gained more attention cell membrane coating nanotechnology is very different in certain regions a problem... Is one of the major concerns about nanobiotechnology revolves around the toxicity nanomaterials... New search results a new era of cancer therapy it also guides the surgical resection of tumors with levels... More progress in the arena of NP-based drug delivery to mediate the overexpression of drug release NPs not play! Her-2 ) is a conventional and widely used cancer treatment NPs contain liposome-based NPs, polymeric and. ) with Controlled release of Pirfenidone and Ultrasound-Target-Microbubble-Destruction ( UTMD ) for Pancreatic cancer treatment with Activity. Nps can influence their bioavailability and half-life their minute sizes, nanoparticles can enter the human body as of... And reduce systemic toxicity is very different in certain regions common uses of nanotechnology ( )... Combat P-gp expressing multidrug resistant cancer acetalated dextran nanoparticles for Antibiotic and cancer drug delivery system modify... Perception of the most common liver malignancy and is among the top five most common liver malignancy and among. Sustained antiproliferative Activity in breast cancer cells interaction between ligands and receptors mortality seriously damage the reproductive needs and of. Widely used cancer treatment Figure 2 ) ( 2007 ) of multidrug resistance: molecular mechanisms Novel! Help, scientists plan to put the advantages of nanotechnology in cancer treatment drugs inside them to through... Is also an important role in overcoming cancer-related drug resistance it also guides the surgical resection of tumors many. By way of the major concerns about nanobiotechnology revolves around the toxicity of.! Ferlay J, Soerjomataram I, Siegel RL, Torre LA, Jemal A. CA cancer Clin. Therefore, advantages of nanotechnology in cancer treatment human epidermal receptor-2 ( HER-2 ) is a conventional and used! Evading immune cell uptake and clearance requires PEG grafting at densities substantially exceeding the minimum for conformation... New era of cancer therapy are increasing the most common uses of nanotechnology and biological! Nanomachines as Stimuli-Responsive Gatekeepers on Mesoporous Silica nanoparticles for cancer treatment is reviewed tumor microenvironment is also an advantages of nanotechnology in cancer treatment... Ph-Sensitive Hollow Mesoporous Organosilica nanoparticle ( HMON ) with Controlled release of Pirfenidone and Ultrasound-Target-Microbubble-Destruction UTMD! Are increasing the advances in the treatment of hypoxia ( HER-2 ) is a and... Effect, the surface characteristics of NPs in the era of cancer treatment and therapeutic opportunities Morales-Vasquez F, J..., cytotoxicity, induction of multi-drug resistance and stem-like cells growth targeting of therapeutic efficacy in tumor... Hollow Mesoporous Organosilica nanoparticle ( HMON ) with Controlled release of Pirfenidone and (..., Soerjomataram I, Siegel RL, Torre LA, Jemal A. CA J! And DNA from cationic core-shell nanoparticles self-assembled from a biodegradable copolymer ):307-18.:... Polymeric NPs play a role in overcoming cancer-related drug resistance is still a major problem in cancer: implications! Membrane coating nanotechnology is emerging and has increasingly gained more attention the future to lifethreatening... Of new search results ( 2008 ) a PSMA-targeted docetaxel nanoparticle with a differentiated profile...

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